TG02 _EU Patent for mutant-RAS neoantigen
Targovax granted EU Patent for mutant-RAS neoantigen platform 2nd generation product TG02
Provides IP protection of TG02 in Europe until 09.12.2033
Oslo, 19 June 2018: Targovax ASA (“Targovax” or “the Company” OSE: TRVX), is a clinical stage company focused on developing and commercializing immune activators to target hard to treat solid tumors, announces that the European Patent Office has granted European Patent no 3079715, A Peptide mixture. The patent protects the composition of Targovax's mutant-RAS specific neoantigen vaccine TG02, for stimulating the immune system of cancer patients with RAS mutated tumors.
Targovax’s proprietary mutant-RAS neoantigen vaccine platform is designed to treat patients with tumors harboring RAS mutations. Mutations in the RAS genes are a driving cause of cancer development and progression, and is linked to poor prognosis. By inducing an anti-mutant-RAS specific immune response, the TG products have the potential to delay disease progression and increase survival, with a favorable safety profile compared to chemotherapy and many other treatment options.
TG02 expands the coverage of RAS mutations beyond TG01, and is targeting all relevant RAS exon 2 oncogenic point mutations which are found in the vast majority of all RAS mutated cancers. Currently, TG02 is being tested in an exploratory Phase Ib clinical trial in patients with locally recurrent RAS-mutated colorectal cancer in combination with the checkpoint inhibitor KEYTRUDA® (clinical study CT TG02-01). This study will provide important clinical data on the safety, immune activation and mechanism of action of TG02.
Jon Amund Eriksen, inventor of the TG technology and Co-founder of Targovax, said: "We are glad to see the European patent for TG02 being granted, further strengthening Targovax's intellectual property portfolio covering the very important mutant-RAS trunk neoantigens. RAS is mutated in 20-30% of all cancers, and this 2nd generation product from the TG platform puts Targovax in a position to address an important unmet medical need, which could eventually benefit all RAS mutated cancer patients."
Provides IP protection of TG02 in Europe until 09.12.2033
Oslo, 19 June 2018: Targovax ASA (“Targovax” or “the Company” OSE: TRVX), is a clinical stage company focused on developing and commercializing immune activators to target hard to treat solid tumors, announces that the European Patent Office has granted European Patent no 3079715, A Peptide mixture. The patent protects the composition of Targovax's mutant-RAS specific neoantigen vaccine TG02, for stimulating the immune system of cancer patients with RAS mutated tumors.
Targovax’s proprietary mutant-RAS neoantigen vaccine platform is designed to treat patients with tumors harboring RAS mutations. Mutations in the RAS genes are a driving cause of cancer development and progression, and is linked to poor prognosis. By inducing an anti-mutant-RAS specific immune response, the TG products have the potential to delay disease progression and increase survival, with a favorable safety profile compared to chemotherapy and many other treatment options.
TG02 expands the coverage of RAS mutations beyond TG01, and is targeting all relevant RAS exon 2 oncogenic point mutations which are found in the vast majority of all RAS mutated cancers. Currently, TG02 is being tested in an exploratory Phase Ib clinical trial in patients with locally recurrent RAS-mutated colorectal cancer in combination with the checkpoint inhibitor KEYTRUDA® (clinical study CT TG02-01). This study will provide important clinical data on the safety, immune activation and mechanism of action of TG02.
Jon Amund Eriksen, inventor of the TG technology and Co-founder of Targovax, said: "We are glad to see the European patent for TG02 being granted, further strengthening Targovax's intellectual property portfolio covering the very important mutant-RAS trunk neoantigens. RAS is mutated in 20-30% of all cancers, and this 2nd generation product from the TG platform puts Targovax in a position to address an important unmet medical need, which could eventually benefit all RAS mutated cancer patients."
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