Farma

Yngling ØH
23.01.2021 kl 02:10 3696

Pfizer sier vaksinen virker mot nye mutasjoner.
https://amp.ft.com/content/943c8ca9-0c92-4366-8ab4-b569a1e123b8?__twitter_impression=true

Studien jeg lenket over viser hvorfor Pfizer tar feil.
Når forskerne testet mutasjonene en, for en, så virket vaksinen mot alle mutasjonene. Men når forskerteamet satte sammen en kombinasjon av mutasjoner, lik den i B.1.1.7, så unnslapp viruset vaksinen hos mange av deltagerne.

"The study team next engineered a pseudovirus to express
spike protein that included the full set of mutations present
in the B.1 .1 .7 variant (de169/70, del 144/145, N501 Y, A570D,
P681 H, T7161, S982A, DI 1 18H).
Significantly when sera were tested against this full set
of B.1.1.7 spike mutations, neutralization titers were
reduced among the vaccinated individuals.
It was found that among 15 individuals who had exhibited
neutralization activity three weeks following vaccination, lO
showed evidence of a reduced antibody response against the
B.1 .1 .7 mutant.

On the whole, reduction in efficacy was less than 3-fold,
while the most significant reduction was around 6-fold..."

..."The study team said, 'These changes are what we expected
to see given the mutational profiles."
They warned further research is needed to investigate the
impact of these observations on real-life vaccine efficacy.
The study team said, "Other variants also need to be tested
against vaccine sera, some with more concerning mutations
such as E484K and K417N that have been shown to impact
neutralization by monoclonal antibodies or convalescent
sera."

https://www.thailandmedical.news/news/vaccine-news-cambridge-study-shows-that-pfizer-biontech-vaccine-exhibits-reduced-neutralization-potential-against-sars-cov-2-b-1-1-7-variant
Redigert 23.01.2021 kl 02:12

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