ArcticZymes has entered into an agreement with ReiThera to supply its SAN product for ReiThera's COVID-19 vaccine candidate

Tromsø, 02 July, 2020: ArcticZymes AS (OSE:AZT), a subsidiary of ArcticZymes
Technologies ASA, announces that it has entered into a supply agreement with
vaccine specialist ReiThera Srl (Rome, Italy) for the supply of Salt Active
Nuclease (SAN-HQ) to be used in the development and manufacturing of ReiThera's
novel vaccine candidate against COVID-19. The vaccine candidate, which is based
on ReiThera's viral vector technology, is scheduled to enter clinical trials
soon.

SAN-HQ has established itself within the viral vector-based biopharmaceutical
segment, where viruses are used to deliver genetic material into cells to treat
or prevent disease. Due to safety concerns, regulators require manufacturers to
minimize and control the amount of exogenous nucleic acids impurities (DNA or
RNA not encapsulated by the vector) in the final dosage. Therefore, one or more
nuclease treatments are often implemented in the downstream processing of the
virus, in which the nuclease digests exogenous DNA. Exogenous DNA can also cause
the viral particles to aggregate, which reduces both yield and potency of the
vector. One of the key strategies to reduce aggregation involves keeping the
virus at elevated salt concentrations. Unlike other commercially available
nucleases, SAN-HQ digests nucleic acids with high efficiency at high salt
concentrations. Furthermore SAN-HQ is utilized at much lower qualities which
means less enzyme needs to be removed from the virus following its use which is
another key advantage.

To put it into context, the manufacturing process of viral vaccines is a
complicated and lengthy multi-stage process with many steps. SAN-HQ is utilised
for one part of this process and does not end up as part of the final
therapeutic vaccine. Hence, the supply deal relates to the provision of this
essential component to streamline part of the process.

ReiThera, together with Leukocare AG (Germany) and Univercells S.A. (Belgium),
has formed a pan-European consortium to fast-track the development of its
vaccine against the novel coronavirus SARS-CoV-2, which causes COVID-19.

ArcticZymes AS, CEO, Jethro Holter said:

"We are delighted to expand our relationship in supporting ReiThera and its
consortium partners with fast tracking its activities to develop a vaccine
against the novel coronavirus SARS-CoV-2. ReiThera is a leading European company
in genetic vaccine development focused on bringing innovative therapeutics to
market via leveraging the best technologies such as ArcticZymes' SAN-HQ. We look
forward to supporting ReiThera in the development and future commercialisation
of their vaccine."

"This agreement seamlessly fits with our efforts to scale up SAN-HQ which is
supported by the Innovation Norway funding recently granted to ArcticZymes in
May 2020. The timely scaling of SAN-HQ production will satisfy future
commercial demand from our partners such as ReiThera."

ReiThera's Project Manager, Marco Soriani, said:

"ReiThera's effort to develop a vaccine against the coronavirus that causes
COVID-19 relies on its solid partnerships with key pharmaceutical stakeholders,
such as ArcticZymes, which provide crucial technologies to ensure a consistently
high-quality product. We look forward to working with ArcticZymes on this
important product development program, which aims to tackle the global COVID-19
pandemic."

-ENDS-