Regner med at ditt sitat er «gått ut på dato», hvis ikke ville ikke Merck ha informert om at det ikke finnes medisiner mot sykdommen.

Jeg siterer fra Merck web side - se nederste avsnitt !

https://www.merck.com/stories/hpv-awareness/

« A common virus that can cause certain cancers in both men and women
HPV is a common virus that can have potentially serious consequences. In fact, HPV is so common that a majority of sexually active people will become infected in their lifetime. For most people, HPV clears on its own. But, for others who don’t clear the virus, it can cause certain cancers and other diseases. And there’s no way to predict who will or won’t clear the virus.

HPV doesn’t discriminate. Both men and women are at risk for the certain cancers and diseases it can cause. In women, HPV can cause cervical, vaginal and vulvar cancer. It can also cause anal cancer and genital warts in both women and men.

The impact of HPV
icon
~14M
The estimated number of people in the U.S. infected with HPV each year.
icon
~23,230
2015 estimated U.S. incidence of cervical, vulvar, vaginal and anal cancers.
icon
~80%
The probability of being infected with HPV by age 45 among sexually active people in the U.S.


0 - ZERO - NULL - INGEN - NADA
The number of treatment options for HPV infection.

While there may be treatments available for certain HPV-related cancers and diseases, there is no treatment available for HPV infection.»

Statens legemiddelverk.
Det er mangel på Gardasil 9 «MSD Vaccins». Årsak til mangelen er økt etterspørsel internasjonalt. Forventet leveringstid er 1. kvartal 2021
Gardasil 9 inneholder rekombinant Humant Papillomavirus (HPV) og brukes til aktiv immunisering mot HPV-relaterte premaligne lesjoner, kjønnsvorter og kreft.

Legemiddelverket har frem til 31. juli 2020 mottatt til sammen 1165 bivirkningsmeldinger etter at nesten 540 000 personer har blitt vaksinert med minst en dose HPV-vaksine i Norge. I all hovedsak betegnes bivirkningene som lite alvorlige.

https://www.felleskatalogen.no/medisin/gardasil-9-msd-vaccins-633598

Ta imot gode råd fra Merck - ikke mer fra meg :

« For more information about HPV, certain related cancers and preventative measures, speak with your doctor»

Gardasil 9 is an HPV vaccine approved by the U.S. Food and Drug Administration and can be used for both girls and boys. This vaccine can prevent most cases of cervical cancer if given before a girl or woman is exposed to the virus.

Hør gjennom siste presentasjoner.
NSCLC dataene som er presentert tidligere, er såkalte "umodne" data. Dvs det tar tid før man kan se hva den faktiske forskjellen i bedring og overlevelse blir.
For å være godt forberedt til presentasjonen kan det nok være lurt å se gjennom siste NSCLC ppt /pdf presentasjon.
AML studiene viste svært gode resultat, så der kan vi nok forvente at BGBIO lykkes med å finne en partner i løpet av 2021.
De umodne NSCLC dataene har ikke vert like overbevisende. Og det er NSCLC som det er mest penger i. Det blir derfor spennende å se hva de kommer med.

Legislation[edit]
Shortly after the first HPV vaccine was approved, bills to make the vaccine mandatory for school attendance were introduced in many states.[171] Only two such bills passed (in Virginia and Washington DC) during the first four years after vaccine introduction.[171] Mandates have been effective at increasing uptake of other vaccines, such as mumps, measles, rubella, and hepatitis B (which is also sexually transmitted).[165] However most such efforts developed for five or more years after vaccine release, while financing and supply were arranged, further safety data was gathered, and education efforts increased understanding, before mandates were considered.[171] Most public policies including school mandates have not been effective in promoting HPV vaccination while receiving a recommendation from a physician increased the probability of vaccination.[172] The FDA approved Gardasil 9 for women and men ages 27 to 45 in October 2018.[1

https://www.bbc.co.uk/programmes/p09555tc

Vaksine / COVID-19 nytt fra BBC - podcast:
https://open.spotify.com/episode/1SI7U2kqPSIswzivFmhz0Q?si=30gYNESOQhKF8J2WHFjIxQ

Flott tilbud for alle som ønsker å leve «det gode liv» på Barbados under COVID-19.

“Working remotely from Barbados 🇧🇧 is seem less”
Manhattan Investment Banker working from the Beach


https://open.spotify.com/episode/5q06ivFOkeDkshZJEl2yBR?si=Q8OWUr8fRgu9YBYVmoUMrQ

Mulig denne studien som er publisert i Nature er kommentert tidligere. Det er tydeligvis mange kompetente her på forum. Hva er deres kommentar til konklusjonen neders og relevans for Bergen Bio?
Abstract
The current coronavirus disease 2019 (COVID-19) pandemic presents a global public health challenge. The viral pathogen responsible, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), binds to the host receptor ACE2 through its spike (S) glycoprotein, which mediates membrane fusion and viral entry. Although the role of ACE2 as a receptor for SARS-CoV-2 is clear, studies have shown that ACE2 expression is extremely low in various human tissues, especially in the respiratory tract. Thus, other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist. In this study, we found that the tyrosine-protein kinase receptor UFO (AXL) specifically interacts with the N-terminal domain of SARS-CoV-2 S. Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2, we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2, while knocking out AXL significantly reduces SARS-CoV-2 infection in H1299 pulmonary cells and in human primary lung epithelial cells. Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL. The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients. Taken together, our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies.

Trekker ut essensen.
while knocking out AXL significantly reduces SARS-CoV-2 infection in H1299 pulmonary cells and in human primary lung epithelial cells. Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL. The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients. Taken together, our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role..

Noen som tviler på kommende Covid oppdatering?

Jepp, forventer solid oppgang i morgen og neste uke i påvente av melding (er) starter allerede i morgen.

Ligger godt ann til rally siden timen i påvente av morgendagens nyheter 👍

Presentasjonen er vel i natt? Det er vel ikke særlig trolig med store nyheter da? De vil vel evt komme senere i en ordinær melding? Men kursen går vel sikkert noe før stengetid i dag, men ikke voldsomt mye. Kanskje 34-35 om man tar i skikkelig? Så litt ned igjen i morgen pga skuffede håpefulle i forhold til presentasjonen? Så kommer det en melding eller fem en gang i løpet av vinteren som gjør susen!

Jeg har trua på andre nyheter neste uke .

Personlig tror jeg fase3 er nært forestående , ref melding fra i 20

Videre opplyses det at styret er stadig mer overbevist om at fortsatt lovende data fra studier av bemcentinib i AML, MDS og NSCLC representerer klinisk "proof of concept" for AXL-hemming i kreftterapi, noe som garanterer ytterligere undersøkelser i avgjørende forsøk.

Det blir spennende nå fremover - Vi kommer jo nærmere for hver dag som går. Vi får håpe de kommer med kursdrivende meldinger slik at stemningen blir på topp. 👍

Ny studie indikerer at asymptomatisk smitte er vanligere enn vi har trodd.

"The corrections due to the serological test sensitivity (in particular those ones depending on the symptoms onset) make the comparison between data and models less accurate. conclusions: The predictions of the model confirm a relevant presence of asymptomatic individuals also during the second pandemic wave in Italy. The ratio of reported to unreported cases is predicted to be roughly 1:4..."
https://www.medrxiv.org/content/10.1101/2021.01.27.21250597v1

Hvordan viruset har utviklet seg, og alvorlighetsgraden til de ulike variantene:
https://www.bbc.com/future/article/20210127-covid-19-variants-how-mutations-are-changing-the-pandemic

"Will Covid-19 evolve resistance to vaccines?"
https://www.bbc.com/future/article/20210119-covid-19-variants-how-the-virus-will-mutate-in-the-future

"Menu

COVID-19

Will Covid-19 evolve resistance to vaccines?

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(Image credit: Oscar Del Pozo/Getty Images)

By Richard Gray

20th January 2021

Every time the coronavirus passes from person to person it picks up tiny changes to its genetic code, but scientists are starting to notice patterns in how the virus is mutating.

Article continues below

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For more than three months the patient struggled against Covid-19. His immune system was already in a bad way when he caught the virus – he had been receiving a drug treatment for lymphoma, a type of blood cancer, that depleted some of his immune cells. With fewer of the usual defences against infection, the virus was able to spread in his body relatively unchecked.

As doctors tried to help the elderly patient fight the virus, they gave him blood plasma collected from people who had already recovered from Covid-19. Contained within this milky-brown liquid – also known as convalescent plasma – were antibodies against the virus that might help to neutralise it.

Over the course of 101 days as they treated the man, clinicians at Addenbrookes Hospital in Cambridge, UK, took 23 swab samples as he fought against the disease. Each swab was sent off to a nearby laboratory to be analysed. But when virologists looked at the virus’s genetic material in the samples, they noticed something astonishing – Covid-19 was evolving before their eyes.

"We saw some remarkable changes in the virus over that time," says Ravinda Gupta, an infectious diseases consultant at the hospital and a clinical microbiologist at the University of Cambridge who analysed the patient’s samples. "We saw mutations that seemed to suggest the virus was showing signs of adaptation to avoid the antibodies in the convalescent plasma treatment. It was the first time we had seen something like this happening in a person in real time."

Nearly a year after the global Covid-19 pandemic started, the issue of mutations looms large. New variants capable of spreading faster are emerging and leading to inevitable questions about whether they will make the newly approved vaccines less effective. To date, there is little evidence they are, but scientists are already starting to explore how the Covid-19 virus will mutate in the future and whether they might be able to head it off. In the first of a two part series looking at Covid-19 mutations, we look at what they have learned so far.

Story continues below

The worldwide effort to test and sequence samples of Covid-19 is helping to reveal new variants as they emerge (Credit: Jeff Pachoud/Getty Images)

Among the mutations Gupta and his colleagues identified was a deletion of two amino acids – known as H69 and V70 – in the spike protein sitting on the outside of the Covid-19 virus. This protein plays a key role in the ability of the coronavirus to infect cells.

The oily capsule that surrounds most of the virus is studded with these spikes sticking outwards, making it look like a crown when viewed through an electron microscope. It is this appearance that gives the coronavirus family its name – corona is Latin for crown. The spikes are also the main way Covid-19 recognises the cells it can infect and helps the virus penetrate them.

When Gupta and his team looked closer at the spike protein deletion they had spotted, it produced worrying results. "We did some infection experiments using artificial viruses and they showed that the H69/V70 deletion mutation increases the infectivity by twofold," says Gupta. This prompted the researchers to scour the international genetic databases of Covid-19. There they found that something more alarming was taking place.

"We wanted to see what was happening worldwide and we stumbled upon this big expanding group of [H69/V70 deletion] sequences in the UK," says Gupta. "When we looked more closely, we found that there was a new variant causing a big outbreak."

Even as they made this discovery in early December last year, infectious disease experts elsewhere in England were struggling to understand rapidly rising case numbers in London and the south-east of England despite a national lockdown. They started to notice something strange in the results of Covid-19 tests being carried out on samples.

To me these seem like a glimpse into the future where we are going to be in an arms race with this virus – Michael Worobey

The main diagnostic tool for Covid-19 has been polymerase chain reaction (PCR) tests, which search for traces of the virus's genetic material in samples. Usually, it targets three parts of the virus to confirm the presence of an infection. But one of these targets was increasingly coming back negative in samples from the areas of England with rapidly rising case numbers, while the other two targets in the tests continued to work.

"We were not missing cases but it is unusual to see two of the tests working but a third not," Wendy Barclay, a virologist at Imperial College London and a member of the UK’s New and Emerging Respiratory Virus Threats Advisory Group, told the BBC’s Today programme on 22 December.

The part of the virus that this part of the PCR test targeted was a sequence on the spike protein. When the scientists delved deeper, they found that the virus in these samples had picked up a mutation – a deletion at the same H69 and V70 positions in the protein seen by Gupta – that meant the PCR test was failing to pick it up sometimes.

Alongside this genetic change, they also found 16 other mutations that had altered the viral proteins they coded for, including several on the spike protein. What they had discovered was a new lineage of the Covid-19 virus that had picked up multiple mutations over a relatively short period of time. They designated it B117 – the new British Covid-19 variant, also known as VOC 202012/01 in the messy world of coronavirus nomenclature. It has cut a swathe across the UK and had spread to 50 other countries by mid-January.

The spike proteins (red) that stud the surface of the Covid-19 virus help it to get inside cells, but are also targetted antibodies (Credit: CDC/Getty Images)

The emergence of this new variant – which is estimated to be 50-75% more transmissible than the original Covid-19 virus – along with others now being detected such as the South African and Brazilian variants, has shone a spotlight on how the coronavirus is mutating as the pandemic rumbles on. It has also raised concerns about how it might continue to change in the future as we try to fight it with vaccines.

"To me these seem like a glimpse into the future where we are going to be in an arms race with this virus, just like we are with flu," says Michael Worobey, a viral evolutionary biologist at the University of Arizona. Each year the flu vaccine has to be updated as the influenza virus mutates and adapts to escape the immunity already present in the population, says Worobey. If the coronavirus shows similar capabilities, it could mean we will have to adopt similar tactics to keep it at bay, by regularly updating vaccines.

You might also like:

How effective is a single vaccine doseThe insect that kills 1 million people a yearThe 432-year-old manual on social distancing

Many believe that drug companies should already be updating their vaccines to target mutated versions of the Covid-19 spike protein. But can the patterns of mutations scientists are seeing popping up in Covid-19 around the world offer any clues about how the virus will continue to evolve?

"It is hard to speculate, but it is interesting that all of a sudden there does seem to be a lot of mutations appearing that could be associated with immune escape or immune recognition," says Brendan Larsen, a PhD student working with Worobey in Arizona. He recently identified a new variant of Covid-19 circulating in Arizona that has the H69/V70 deletion seen in several other versions of the virus. While still only spreading at a relatively low level there and in other states of the US, it suggests that this particular mutation is recurring independently around the world, says Larsen.

This repeated occurrence of the same mutations in different variants provides some clues as to what is going on – as the virus has spread through millions of people, it may be facing similar evolutionary pressures that are causing it to change in particular ways.

In most viruses and disease-causing bacteria, the use of treatments and vaccines causes them to evolve ways of escaping them so they can continue to spread

"By themselves they are likely to have a minor impact overall," says Larson. "But together all of these different mutations might make it more difficult for the immune system to recognise the virus." This could then lead to more patients catching the disease twice and perhaps also mean the vaccines may need to be altered.

"Even a relatively small amount of immune escape could make it harder to achieve herd immunity," adds Worobey.

Researchers in Illinois have also recently identified another new variant, called 20C-US, which has a number of unique and specific mutations that may alter the virus’s ability to replicate itself once inside human cells. It also features a mutation close to a site on the Covid-19 spike protein that is thought to have been crucial in allowng the virus to jump species to humans towards the end of 2019..."

"Our findings suggest that vaccines that do not prevent infection will allow extensive endemic SARS-CoV-2 spread upon a return to pre-pandemic social and economic conditions. Vaccines that only reduce symptomatic COVID-19 or mortality will fail to mitigate serious COVID-19 mortality risks, particularly in the over-65 population, likely resulting in hundreds of thousands of US deaths on a yearly basis."
https://www.medrxiv.org/content/10.1101/2021.01.27.20240309v1

Accord oppdatering - like før nyheter fra BGBIO ?

https://www.pharmaceutical-journal.com/news-and-analysis/features/everything-you-need-to-know-about-the-covid-19-therapy-trials/20208126.article?firstPass=false

Everything you need to know about the COVID-19 therapy trials

The Pharmaceutical Journal26 JAN 2021By Julia Robinson
There are thousands of clinical trials investigating treatments and preventative measures for COVID-19.

Bemcentinib

Selectively inhibits AXL kinase, which blocks viral entry and enhances the antiviral type I IFN response;
Investigational treatment for COVID-19;
Reported to exhibit potent anti-viral activity in pre-clinical models against several enveloped viruses, including Ebola and Zika virus.
Ongoing trials

A Multicentre, Seamless, Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID 19 in Hospitalised Patients (ACCORD-2-001).


https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001736-95/GB#E



Kan noen forklare dette ?
Nederst på web siden leser vi :

«The status of studies in GB is no longer updated from 1.1.2021
For the UK, as from 1.1.2021, EU Law applies only to the territory of Northern Ireland (NI) to the extent foreseen in the Protocol on Ireland/NI
EU Clinical Trials Register Service Desk: https://servicedesk.ema.europa.eu
European Medicines Agency © 1995-Mon Feb 01 22:30:09 CET 2021 | Domenico Scarlattilaan 6, 1083 HS Amsterdam, The Netherlands».

Antar det har noe med at GB ikke lenger er en del av EU, og at det derfor ikke kommer flere oppdateringer på sidene til clinicaltrialsregister.eu .

Det kan kanskje få konsekvenser at UK ikke lengre er med i EU, men det er litt vanskelig å lese seg opp på dette for menigmann, som meg.
Jeg håper selskapet etter hvert kan dele noen tanker om dette. Det jeg leser meg frem til er at samarbeidet innen godkjennelser av medisin og medisinsk forskning skal fortsette med samme standarder etc, men at det kanskje oppstår noe mer formaliteter og byråkrati for selskap som ønsker medisiner godkjent.

Here we show functionalized nanoparticles, termed "Nanotraps", completely inhibited SARS-CoV-2 infection by blocking the interaction between the spike protein of SARS-CoV-2 and the ACE2 of host cells.
https://www.biorxiv.org/content/10.1101/2021.02.01.428871v1

https://www.abcnyheter.no/nyheter/verden/2021/02/02/195737289/britisk-coronavariant-har-mutert-pa-nytt-forskerne-frykter-tapt-immunitet

"British scientists say the next dangerous Covid variant is likely already out there. We just don't know it yet"
https://edition.cnn.com/2021/02/03/europe/tracing-uk-variant-origins-gbr-intl/index.html

A new paper released this week suggested that a vaccine developed by AstraZeneca and Oxford University not only protected clinical trial participants from developing disease, but also may significantly reduce transmission of the virus that causes the disease.

In the recent burst of data on Covid-19 vaccines, that suggestion stood out. The question of whether Covid-19 vaccines reduce transmission has been a critical and unanswered one, creating uncertainty over whether people who have been vaccinated will still be able to be infected by and transmit onward SARS-Cov-2, the virus that causes Covid, to those who have not yet been vaccinated. 

Media reports seized on a reference in the paper from Oxford researchers that a single dose of the vaccine cut positive test results by 67%, pointing to it as the first evidence that a vaccine could prevent transmission of the virus. But the paper, which has not yet been peer-reviewed, does not prove or even claim that — although it hints at the possibility.
.... mer i artikkelen...
https://www.statnews.com/2021/02/03/with-a-seductive-number-astrazeneca-study-fueled-hopes-that-eclipsed-its-data/

Er dette «FORSKNING OG MEDISINER RELATERT TIL BerGenBio»?

Kommende konkurrent?

"Increasing data suggests UK variant may be deadlier, says CDC director"
https://edition.cnn.com/world/live-news/coronavirus-pandemic-vaccine-updates-02-04-21/h_3d96e0765677dcf6617fd51dbfa8efce

Det at et virus muterer slik at det blir mer dødelig er i strid med det virologer uttalte tidlig i pandemien, der de hevdet at viruset ville bli mindre farlig etter hvert som det muterte.

CONCLUSIONS: In COVID-19 patients requiring mechanical ventilation, sufficiently dosed methylprednisolone can lead to a further decreased mortality as compared to dexamethasone.
https://www.medrxiv.org/content/10.1101/2021.02.03.21251088v1

Oxford/AstraZeneca Covid jab far less effective against S African strain, study shows

https://www.ft.com/content/e9bbd4fe-e6bf-4383-bfd3-be64140a3f36

Se følgende studie:
https://pubmed.ncbi.nlm.nih.gov/29474201/

Betyr dette at kraftig hosting øker Axl? ... og at kraftig hosting hos covid pasienter dermed forverrer lungesykdommen? ... men at bemxentinib hemmer Axl - shedding.
Kanskje en (lavdose) calcium channel blocker burde prøves ut i kombinasjon med bemcentinib?

https://www.tv2.no/nyheter/11941948/

Oppdatert vaksine mot Sør-Afrika varianten er først klar til høsten en gang.

Syd-Afrika har nettopp meldt ut at de ikke vil bruke (har suspendert) Astra Zeneca-vaksinen p.g.a. dårlig effekt mot Covid-19 mutasjonen i S-A. (nyhet via BBC i kveld).

Twittermelding:
"⚠️SURGING #B117 WITHIN US—growing 7% per day, doubling every 9.8 days nationally, & expected to become dominant by March 23rd. It is surging fastest in Florida—doubling every 9.1 days. Scientists are extremely worried: 35-45% more transmissible.🧵#COVID19
https://t.co/T3GV8anzYz https://t.co/RFyifNq4QS"
Ser ut som det er Washington Post som er kilde. Har brukt opp mine gratisartikler der for lengst.

Ca 1 av 3 smittede får ikke coronasymptomer, og blir skjulte smittebærere viser ny meta-studie.

https://www.abcnyheter.no/helse-og-livsstil/helse/2021/02/07/195737504/en-av-tre-corona-smittede-hadde-ikke-symptomer?utm_source=upday.samsung.browser&utm_medium=referral

Fant denne studien som viser at Bemcentinib er blant de ledene kandidater innen medisin mot Ebola og COVID-19 :

Krever innlogging :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302206/

( uviss dato , men oppdatert i 2021 )

Det hadde vert helt fantastisk. I henhold til dagens situasjon synes eg det går alt for lang tid. Må da kunne se resultater som e gode eller dårlig nok. Vi er midt i en krise!!

https://www.nature.com/articles/s41422-020-00460-y