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Oppdatert 24.oktober:

"Circio selected to present its circVec circular RNA expression platform at the
European Society of Cell and Gene Therapy (ESGCT) annual meeting in Rome 22-25
October; a prestigious and widely attended international gene therapy conference
· Circio presented new circVec protein expression data showing statistically
significant advantage vs. conventional mRNA-based vector expression both in
vitro and in vivo
· The circVec 2.1 generation shows 15x increase in protein expression in vivo,
and has the potential to substantially improve on the performance of current
gold-standard gene therapy approaches

Oslo, Norway 24 October 2024 - Circio Holding ASA (OSE: CRNA), a biotechnology
company developing next generation circular RNA vector technology for gene
therapy, today announces the publication of new, strong and statistically
significant circVec circular RNA in vivo expression proof-of-concept data,
presented both in the form of a poster and oral presentation by CTO, Dr. Thomas
B Hansen, at the European Society of Cell and Gene Therapy (ESGCT) annual
meeting 2024.

"Circio continues to build momentum with the unique and powerful circVec
platform. We selected the prestigious ESGCT meeting to present our latest
results as it provided a great opportunity to showcase our technology to a broad
life science industry and academic audience," said Dr. Thomas B. Hansen, CTO of
Circio. "circVec significantly outperforms mRNA-based expression both in vitro
and in vivo and has the potential to offer substantial enhancement over current
gold-standard gene therapy approaches."

In the ESGCT presentation, Circio showed the evolution and improvements of the
circVec platform from the initial circVec 1.0 design to the current generation
2.1. Long-term in vivo experiments have now demonstrated that circVec 2.1
robustly outperforms classical mRNA-based expression over time, offering
enhanced durability that reaches up to 15-fold higher reporter signals in mouse
models. Additionally, a machine-learning approach to codon optimization has
generated a novel circVec 2.2 design, delivering a further 2-4-fold increase in
protein yield.

Circio is currently testing the performance of circVec 2.1 and 2.2 in both viral
and DNA vector systems in multiple tissues and disease settings in vivo. These
data will guide future development and partnering strategy for the circVec
platform"


Oslo, Norway 19 November 2024 - Circio Holding ASA (OSE: CRNA), a biotechnology
company developing next generation circular RNA vector technology for gene
therapy, today announces that it has entered a collaboration with Certest
Biotec, S.L. for formulation of circVec into lipid nanoparticles (LNPs) for
tissue specific delivery of DNA-vectors to address genetic disease.

"Circio´s powerful circVec-DNA technology achieves more than six months
durability in mouse models on a single intra-muscular injection, with up to 15
-fold increase in payload expression levels vs. standard mRNA-based vector
systems" said Dr. Victor Levitsky, CSO of Circio. "Based on these promising
findings in vivo, we are now looking for targeted delivery technology that can
enable therapeutic application of circVec in specific tissues and diseases of
high unmet medical need. We selected Certest as a preferred partner for circVec
-LNP formulation due to the impressive tissue specificity demonstrated for their
proprietary nanoparticles."

"The library of ionizable lipids developed by our team is engineered for a wide
range of nucleic acid payloads, exhibiting a great delivery capacity in
preclinical studies and allows the production of thermostable LNPs." explained
Dr. Juan Martínez Oliván, CSO of Certest Pharma, specialized unit in nucleic
acids delivery systems at Certest Biotec. "Our capability to passively target
different tissues unlocks the possibility to treat organ-specific diseases. We
are very enthusiastic about the joint formulation of Circio's new approach to
circular RNA vector technology with our versatile ionizable lipids, creating a
unique LNP-strategy for gene therapy treatment."

Under the collaboration, Certest has successfully performed packaging and in
vitro validation of circVec-LNP formulations targeted for delivery to lung,
liver and spleen, with positive technical results. Circio will now test these
circVec-LNP formulations in vivo during the next 3-6 months to assess delivery
efficiency, expression level and durability. If successful, these experiments
can pave the way to development of multiple circVec therapeutic candidates in
the field of genetic diseases for both in-house development and partnering"