TARGOVAX: TARGOVAX SIGNS CLINICAL COLLABORATION AGREEMENT WITH THE PARKER INSTITUTE FOR CANCER IMMUNOTHERAPY AND CANCER RESEARCH INSTITUTE

The parties plan to conduct a clinical collaboration trial with Targovax TG mutant RAS vaccine

The collaboration will focus on testing TG vaccination in combination with other treatments in late stage pancreatic cancer

Oslo, Norway, 15 March 2019 - Targovax ASA (OSE: TRVX), a clinical stage biotechnology company developing immune activators to target hard-to-treat solid tumors, today announces that it has entered into an agreement with The Parker Institute for Cancer Immunotherapy (PICI) and the Cancer Research Institute (CRI) for a clinical collaboration with Targovax TG mutant RAS vaccine (TG).

Under the agreement, PICI, CRI and Targovax plan to set up one or more clinical trials with TG, in combination with other immuno-oncology treatments and chemotherapy, in late stage pancreatic cancer. PICI will be the sponsor and responsible for running the clinical trials and scientific analyses, CRI and PICI co-organize the immunotherapy experts, and Targovax will be responsible for TG supply. Targovax may also contribute by partial cost sharing of the trial(s). The design of the first clinical trial is currently under discussion.

(fjernet kontakt og standardinformation til TRVX; se melding for detaljer)

About the Cancer Research Institute

The Cancer Research Institute (CRI), established in 1953, is the worlds leading nonprofit organization dedicated exclusively to
transforming cancer patient care by advancing scientific efforts to develop new and effective immune system-based strategies to prevent, diagnose, treat, and ventually cure all cancers. Guided by a world-renowned Scientific Advisory Council that includes four Nobel laureates and 26 members of the National Academy of Sciences, CRI has invested $384 million in support of research conducted by immunologists and tumor immunologists at the worlds leading medical centers and universities, and has contributed to many of the key scientific advances that demonstrate the potential for immunotherapy to change the face of cancer treatment. CRIs clinical program, the Anna-Maria Kellen Clinical Accelerator, is a unique academic-nonprofit-industry collaboration model that serves as an incubator that delivers multi-center clinical trials for promising new immunotherapy combinations. CRIs venture philanthropy fund supports clinical trials within this program, which fosters a collaborative environment that enables scientists to advance their most ambitious research ideas, and accelerates studies that one group or company could not do alone.

About the Parker Institute

The California, USA, based Parker Institute for Cancer Immunotherapy brings together the best scientists, clinicians and industry partners to build a smarter and more coordinated cancer immunotherapy research effort. The Parker Institute is an unprecedented collaboration between the countrys leading immunologists and cancer centers. The program started by providing institutional support to six academic centers, including Memorial Sloan Kettering Cancer Center, Stanford Medicine, the University of California, Los Angeles, the University of California, San Francisco, the University of Pennsylvania and The University of Texas MD Anderson Cancer Center. The institute also provides programmatic support for top immunotherapy investigators, including a group of researchers at Dana-Farber Cancer Institute, Robert Schreiber, PhD, of Washington University School of Medicine in St. Louis, Nina Bhardwaj, MD, PhD, of the Icahn School of Medicine at Mount Sinai, Philip Greenberg, MD, of the Fred Hutchinson Cancer Research Center, and Stephen Forman, MD, of City of Hope. The Parker Institute network also includes more than 40 industry and nonprofit partners, more than 60 labs and more than 170 of the nations top researchers focused on treating the deadliest cancers. The goal is to accelerate the development of breakthrough immune therapies capable of turning most cancers into curable diseases. The institute was
created through a $250 million grant from The Parker Foundation.